Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening
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comparison of zoe and vitapex for canal treatment of necrotic primary teeth
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15 صفحه اولCompound Cytotoxicity Profiling Using Quantitative High-Throughput Screening
BACKGROUND The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects. OBJECTIVE The National Toxicology Program an...
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In order to identify novel inhibitors of the ATP-binding cassette transporter, ABCG2, a high-throughput assay measuring the accumulation of the ABCG2 substrate pheophorbide a in ABCG2-overexpressing NCI-H460 MX20 cells was used to screen libraries of compounds. Out of a library of 7,325 natural products and synthetic compounds from the National Cancer Institute/Developmental Therapeutics Progra...
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Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human adrenocortical carcinoma cells was used to evaluate the effect of 2060 chemical samples on steroidogenesis via high-performance liquid chromatography followed by tandem mass spectrometry quantification of ...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2012
ISSN: 1479-5876
DOI: 10.1186/1479-5876-10-198